The calciotropic hormones PTH and vitamin D: from bone to blood vessels

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Action of Calciotropic Hormones on Bone Metabolism – Role of Vitamin D3 in Bone Remodeling Events

Vitamin D3 is known to have immunosuppressive effects that can be beneficial for treatment of immune disorders and transplant rejection, however therapeutic application is limited due to hypercalcemia and hypercalcuria. The goal of our studies was to explore both the acute and steady state effects of vitamin D3 on bone remodeling as potential limiting factors to broader use of vitamin D3 in the...

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Effect of smoking and smoking cessation on bone mass, bone remodeling, vitamin D, PTH and sex hormones.

OBJECTIVE To assess the effect of smoking and smoking cessation on bone density, bone remodeling markers, sex hormones, and vitamin D-PTH axis in healthy young subjects. MATERIALS AND METHODS We studied 74 healthy people (31 men, 43 women; mean age 32.2 (7) years) divided into 52 never smokers and 22 smokers, 15 of which stopped smoking for one month. RESULTS Male smokers compared with neve...

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Calciotropic hormones and arterial physiology: "D"-lightful insights.

V ascular calcification increasingly afflicts our aging and dysmetabolic population (1). In the past decade, vascular calcification has emerged as an actively regulated form of calcified tissue metabolism, resembling mineralization of endochondral and membranous bone (1). Demer and colleagues (2) were the first to provide molecular insights into disease pathobiology. In 1993, they identified ex...

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Association of blood pressure, serum vitamin D, calcium and PTH in individuals over 40 in East Tehran

Introduction: Mean systolic and diastolic blood pressures and prevalence of hypertension vary throughout the world. These differences have mostly been explained by changes in diet and racial differences. However, it is believed that other factors such as calcium, vitamin D and PTH status may contribute to its pathogenesis. This study was conducted to assess the association between the serum 25-...

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The Relationship between Thyroid Hormones, Vitamin D and Fasting Blood Glucose Level During Summer and Winter in Nondiabetic Adults

Background and Aims: 25-hydroxy vitamin D3 is recognized to be an essential element for healthy body; however, its deficiency has been identified as a risk factor for thyroid disease, diabetes mellitus and other autoimmune diseases and infectious diseases. Thyroid disease is common in the general population that its prevalence increases proportional to age. Subjects with poorly controlled diabe...

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ژورنال

عنوان ژورنال: Journal of Internal Medicine

سال: 2012

ISSN: 0954-6820

DOI: 10.1111/j.1365-2796.2011.02501.x